Bioactive Small Molecules
Medchemexpress LLC HY-109566 10mg , AZD1390 CAS:2089288-03-7 Purity:>98%
HY-109566 10mg AZD1390 CAS: 2089288-03-7 AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM in cell. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical OrItavncInphosphate 5mg
A semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria; inhibits the growth of clinical isolates of MRSA, MSSA, VREF, VSRF, and other staphylococci, streptococci, and enterococci (MIC90s = ≤0.008-0.5 mg/L); inhibits growth of S. aureus in a neutropenic-mouse thigh model of infection (ED50 = 0.95 mg/kg for single dose); improves survival of mice in an inhalation model of B. anthracis Ames anthrax
Medchemexpress LLC TFMU-ADPr diammonium | 00-00-0 | 98.8% | 805.5 g/mol | C25H32F3N7O16P2 | 5 MG
TFMU-ADPr diammonium is a fluorescent ADP-ribose-based substrate used to monitor poly(ADP-ribose) glycohydrolase (PARG) activity in biochemical assays. Upon enzymatic cleavage the molecule releases a fluorophore, enabling quantitative measurement of PAR hydrolase activity and facilitating inhibitor screening and enzymology studies.
- Releases fluorescent reporter upon PARG cleavage.
- High purity (98.8%) for reproducible assay results.
- High aqueous solubility (125 mg/mL); may require sonication.
- Solid, white to off-white form for easy handling and storage.
- Stable when stored under recommended conditions (-20°C under nitrogen).
Cayman Chemical Bac Strep IB-96212 5mg
A macrolide with antibacterial and anticancer activities; active against M. luteus, B. subtilis, and S. aureus (MICs = 0.4, 100, and 100 UG/ml, respectively); induces death in P388, A549, HT-29, and SK-MEL-28 cancer cells (IC50s = 0.0001, 1, 1, and 1 UG/ml, respectively)
Apexbio Technology LLC BML-210(CAY10433), 537034-17-6, MFCD08062139, 10 mg
MF: C20H25N3O2, MW: 339.43, Solubility: 10.5mg/mL in DMSO. BML-210 (CAY10433) is a novel HDAC inhibitor with IC50 value of 87 uM.
Cayman Chemical ANTIBODY PF-3716556 25mg
A potent and selective H+/K+-ATPase inhibitor; pIC50s = 6.026, 6.038, and 6.009, respectively, for porcine membrane vesicles, and canine and human recombinant cells in ion-leaky (acidic) conditions; 3-fold greater inhibition than revaprazan in ion-tight conditions
Medchemexpress LLC 2,2-dibenzyl-1,3-propanediol | 31952-16-6 | 99.4% | 256.35 | C17H20O2 | 5 G
2,2-Dibenzyl-1,3-propanediol is a drug intermediate used in the synthesis of various active compounds. It is supplied for research use only and is not intended for human therapeutic use.
- Drug intermediate for synthesis applications.
- High purity (99.38%).
- Molecular formula C17H20O2.
- Molecular weight 256.35.
- Pack size 5 g for laboratory use.
Medchemexpress LLC Creatine-13C | 687996-99-2 | 98.5% | 132.13 | 5 MG
Creatine-13C is the 13C labeled Creatine, an endogenous amino acid derivative important for cellular energy, particularly in muscle and brain. This compound is for research use only and not intended for human use.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, like 13C, are incorporated into drug molecules to aid in quantitation during the drug development process.
Medchemexpress LLC HY-103193 10mg , NKH477 CAS:138605-00-2 Purity:>98%
HY-103193 10mg NKH477 CAS: 138605-00-2 NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY TZ9 10mg
A cell-permeable triazine compound that inhibits the human E2 ubiquitin-conjugating enzyme Rad6B; selectively docks to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2/M arrest and apoptosis, and inhibits proliferation and migration of metastatic human breast cancer cells
Medchemexpress LLC LY3522348 (KHK-IN-3) | 2568608-48-8 | 98.3% | 409.41 | 1 ML
KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. It can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes, and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation.
- Ketohexokinase (KHK) inhibitor
- Used in the study of kidney disease
- Used in the study of nonalcoholic steatohepatitis (NASH)
- Used in the study of diabetes
- Used in the study of heart failure
- Inhibits the rate-limiting enzyme KHK in fructose metabolism
- Catalyzes phosphorylation of fructose to fructose-1-phosphate
- For research use only
Cayman Chemical ANTIBODY NIcorndIl 100mg
A SUR2B/Kir6.2 activator (EC50 = ~10 µM) and nitric oxide donor; selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM); activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 = 4.4 µM); decreases mean blood pressure, coronary resistance, and heart rate, as well as increases coronary sinus outflow, in dogs at 1 mg/kg i.v.; increases survival and decreases infarct size in a rabbit model of left coronary artery occlusion-induced myocardial ischemia-reperfusion injury
Medchemexpress LLC Decapeptide-12 | 137665-91-9 | 99.9% | 1395.52 | 10 MG
Decapeptide-12 is a small oligopeptide and a tyrosinase inhibitor that interacts with the C-terminal residue of tyrosinase (Kd: 61.1 μM). It is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM) and also increases the transcription of SIRT. It reduces melanin content in melanocytes and is used for research in melanogenesis, senescence, and inflammation.
- Tyrosinase inhibitor
- Reduces melanin content in melanocytes
- Increases transcription of SIRT
- Used for research of melanogenesis, senescence, and inflammation
- Soluble in H2O (≥ 100 mg/mL or 71.66 mM)
Medchemexpress LLC β-Amyloid (25-35), HFIP-treated | 131602-53-4 | 98.2% | 1060.27 | 5 MG
β-Amyloid (25-35), HFIP-treated is a fragment of the Alzheimer's amyloid β-peptide, demonstrating neurotoxic activities in cultured cells. This product has been treated with HFIP.
- Fragment of Alzheimer's amyloid β-peptide
- Demonstrates neurotoxic activities in cultured cells
- Treated with HFIP
Medchemexpress LLC EBV BZLF1 (190-197) | 200124-17-0 | 1003.24 | 25 MG
EBV BZLF1 (190-197) is an immunodominant CEF-controlling peptide derived from Epstein-Barr virus (EBV). It is a suitable epitope for CD8+ T cells to stimulate the release of IFNg. CTL responses to EBV BZLF1 (190-197) are diverse and cross-recognize similar peptides from both host self-proteins and bacterial proteins. It can be used to study autoimmune diseases.
- Immunodominant CEF-controlling peptide from Epstein-Barr virus (EBV)
- Suitable epitope for CD8+ T cells to stimulate IFNg release
- CTL responses are diverse and cross-recognize similar peptides
- Useful for studying autoimmune diseases